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What is Methylation and Why You Should Care About it


The topic of methylation is getting its fair share of attention lately, and rightly so. Methylation is a simple biochemical process – it is the transfer of four atoms - one carbon atom and three hydrogen atoms (CH3) – from one substance to another.

When optimal methylation occurs, it has a significant positive impact on many biochemical reactions in the body that regulate the activity of the cardiovascular, neurological, reproductive, and detoxification systems, including those relating to:


The body is a very complex machine, with various gears and switches that need to be all functioning properly to operate optimally. Think of methylation, and the opposite action, demethylation, as the mechanism that allows the gears to turn, and turns biological switches on and off for a host of systems in the body.


CH3 is provided to the body through a universal methyl donor known as SAMe (S-adenosylmethionine). SAMe readily gives away its methyl group to other substances in the body, which enables the cardiovascular, neurological, reproductive, and detoxification systems to perform their functions. Unfortunately, the system that produces SAMe is reliant on one switch being turned on by a critical B vitamin, 5-MTHF (also known as active folate or methylfolate).

Simply put, if enough 5-MTHF is present, the methylation cycle will work efficiently.

Folic acid from the diet or supplements must be converted to this active form, 5-MTHF, before it can be used in the body in the methylation cycle.

Unfortunately, approximately 60% of people in the United States have a genetic mutation that makes it challenging for their bodies to create enough 5-MTHF.

When the methylation switch is turned off and isn’t creating enough SAMe, then a number of important molecules cannot be efficiently produced, including:

  • Glutathione

  • Coenzyme Q10

  • Melatonin

  • Serotonin

  • Nitric Oxide

  • Norepinephrine

  • Epinephrine

  • L-Carnitine

  • Cysteine

  • Taurine


First, you can have a simple and easy genetic test to find out if you have a problem with your methylation cycle. This test looks at specific enzymes that are affected by your genetic makeup, including the enzyme MTHFR (methylenetetrahydrofolate reductase), which is the most important enzyme involved in creating 5-MTHF.


In addition to a healthy, whole-food, non-processed food diet, make sure you are eating a lot of these foods:

  • Asparagus

  • Avocado

  • Broccoli

  • Brussels sprouts

  • Green, leafy vegetables

  • Legumes (peas, beans, lentils)

  • Rice

Lifestyle changes include:

  • Engage in regular physical exercise

  • Avoid excessive alcohol consumption

  • Don’t smoke

  • Avoid excessive coffee consumption (not more than five cups daily)


There are seven specific nutrients that can help the methylation cycle achieve optimal performance, even if an individual has the genetic mutation that slows down the methylation cycle. Active folate, active vitamin B12, and active vitamin B6 can all be found in Thorne's Methyl-Guard.

  1. 5-MTHF (active folate)

  2. Methylcobalamin (active vitamin B12)

  3. Pyridoxal 5’-Phosphate (active vitamin B6)

  4. Riboflavin 5’-Phosphate (active vitamin B2)

  5. Magnesium

  6. Betaine (also known as trimethylglycine)

  7. Vitamin D

Proper methylation influences so many systems in our bodies that it often gets overlooked, which can severely impact how well your body functions. Ask your health-care practitioner for advice if you have any concerns about your CH3 cycle.

Blog used by permission. Copyright© 2021 by Thorne Research, Inc. All rights reserved.


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